ACSL3 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | O95573 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 80kDa |
Dilution | ELISA (1 µg/ml), IHC-P (20 µg/ml), WB (1 µg/ml) |
Gene ID | 2181 |
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Other Names | Long-chain-fatty-acid--CoA ligase 3, 6.2.1.3, Long-chain acyl-CoA synthetase 3, LACS 3, ACSL3, ACS3, FACL3, LACS3 |
Target/Specificity | synthetic peptide corresponding to N-terminal residues of human FACL3(long-chain fatty-acid-Coenzyme A ligase 3) |
Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
Precautions | ACSL3 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ACSL3 (HGNC:3570) |
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Synonyms | ACS3, FACL3, LACS3 |
Function | Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). |
Cellular Location | Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).
References
Minekura H.,et al.Genomics 42:180-181(1997).
Minekura H.,et al.Gene 278:185-192(2001).
Yao H.,et al.J. Biol. Chem. 283:849-854(2008).
Daub H.,et al.Mol. Cell 31:438-448(2008).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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