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> home > Products > Primary Antibodies > Antibody Collections > Toll receptor signaling > UEV1 / UEV1A Antibody (aa31-49)
UEV1 / UEV1A Antibody (aa31-49)
Rabbit Polyclonal Antibody
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Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q13404 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 16495 Da |
| Dilution | IHC-P (5 µg/ml), WB (1-3 µg/ml), |
| Gene ID | 7335 |
|---|---|
| Other Names | Ubiquitin-conjugating enzyme E2 variant 1, UEV-1, CROC-1, TRAF6-regulated IKK activator 1 beta Uev1A, UBE2V1, CROC1, UBE2V, UEV1 |
| Target/Specificity | A synthetic peptide corresponding to amino acids 31-49 of human UBE2V1a. Genbank accession no. NP_954595.1. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | UEV1 / UEV1A Antibody (aa31-49) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UBE2V1 |
|---|---|
| Synonyms | CROC1, UBE2V, UEV1 |
| Function | Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1- UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'- linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. |
| Cellular Location | Nucleus. Note=Excluded from the nucleolus |
| Tissue Location | Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung. |
Research Areas
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