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MYO5B / Myosin VB Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9ULV0 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 214kDa |
| Dilution | ELISA (1 µg/ml), IHC-P (2.5 µg/ml), WB (1 µg/ml) |
| Gene ID | 4645 |
|---|---|
| Other Names | Unconventional myosin-Vb, MYO5B, KIAA1119 |
| Target/Specificity | Synthetic peptide corresponding to N-terminal residues of human Myosin-5B (Myosin Vb). |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | MYO5B / Myosin VB Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MYO5B |
|---|---|
| Synonyms | KIAA1119 |
| Function | May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes (PubMed:34816459). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P70569}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.
References
Hirosawa M.,et al.DNA Res. 6:329-336(1999).
Ohara O.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Yamakawa H.,et al.Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
Nusbaum C.,et al.Nature 437:551-555(2005).
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