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SLC2A2 / GLUT2 Antibody
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, ICC, FC |
|---|---|
| Primary Accession | P11168 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 57kDa |
| Dilution | ICC (10 µg/ml), IHC-P (10 µg/ml), |
| Gene ID | 6514 |
|---|---|
| Other Names | Solute carrier family 2, facilitated glucose transporter member 2, Glucose transporter type 2, liver, GLUT-2, SLC2A2, GLUT2 |
| Target/Specificity | Recognizes human GLUT 2 (Glucose Transporter, Insulin Regulatable) expression on hGlut2-transfected NS0 cells but not on control transfectants. Detects Glut2 on the surface of the human intestinal cell line Caco2 in flow cytometry and on fixed cells ... |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
| Precautions | SLC2A2 / GLUT2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC2A2 (HGNC:11006) |
|---|---|
| Function | Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Liver, insulin-producing beta cell, small intestine and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.
References
Fukumoto H.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:5434-5438(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Matsubara A.,et al.J. Clin. Endocrinol. Metab. 80:3131-3135(1995).
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