SLC39A10 / ZIP10 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q9ULF5 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 94kDa |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 57181 |
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Other Names | Zinc transporter ZIP10, Solute carrier family 39 member 10, Zrt- and Irt-like protein 10, ZIP-10, SLC39A10, KIAA1265, ZIP10 |
Target/Specificity | At least three isoforms of ZIP10 are known to exist. This antibody will not cross-react with the zinc transporter ZIP11. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | SLC39A10 / ZIP10 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC39A10 (HGNC:20861) |
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Synonyms | KIAA1265, ZIP10 |
Function | Zinc-influx transporter (PubMed:30520657, PubMed:17359283, PubMed:27274087). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Expressed at the apical membranes of proximal tubules in the kidney. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
May act as a zinc-influx transporter.
References
Nagase T.,et al.DNA Res. 6:337-345(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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