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CFLAR / FLIP Antibody (aa191-209)

Rabbit Polyclonal Antibody

     
  • IF - CFLAR / FLIP Antibody (aa191-209) ALS12667
    Immunofluorescence of FLIP in HeLa cells with FLIP antibody at 10 ug/ml.
    detail
  • IHC - CFLAR / FLIP Antibody (aa191-209) ALS12667
    Anti-CFLAR / FLIP antibody IHC of human lung.
    detail
  • IHC - CFLAR / FLIP Antibody (aa191-209) ALS12667
    Anti-CFLAR / FLIP antibody IHC of human pancreas.
    detail
  • WB - CFLAR / FLIP Antibody (aa191-209) ALS12667
    Western blot of FLIPg/d in total cell lysates from HeLa (H), Jurkat (J), THP-1 (T), A431 (A),...
    detail
  • ICC - CFLAR / FLIP Antibody (aa191-209) ALS12667
    Immunocytochemical staining of HeLa cells using FLIPg/d antibody at 2 µg/ml.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E
Primary Accession O15519
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 55kDa
Dilution IHC-P (5 µg/ml), WB (1:1000),
Additional Information
Gene ID 8837
Other Names CASP8 and FADD-like apoptosis regulator, Caspase homolog, CASH, Caspase-eight-related protein, Casper, Caspase-like apoptosis regulatory protein, CLARP, Cellular FLICE-like inhibitory protein, c-FLIP, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, I-FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, CASP8 and FADD-like apoptosis regulator subunit p43, CASP8 and FADD-like apoptosis regulator subunit p12, CFLAR, CASH, CASP8AP1, CLARP, MRIT
Target/Specificity FLIP antibody was raised against a peptide corresponding to amino acids 191 to 209 at C-terminus of human FLIP form2.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsCFLAR / FLIP Antibody (aa191-209) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CFLAR
Synonyms CASH, CASP8AP1, CLARP, MRIT
Function Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Tissue Location Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle
Research Areas
Citations (0)
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Background

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

References

Shu H.-B.,et al.Immunity 6:751-763(1997).
Han D.K.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:11333-11338(1997).
Irmler M.,et al.Nature 388:190-195(1997).
Srinivasula S.M.,et al.J. Biol. Chem. 272:18542-18545(1997).
Hu S.,et al.J. Biol. Chem. 272:17255-17257(1997).

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Discontinued
Cat# ALS12667
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