STYK1 Antibody (clone 2H2F10)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q6J9G0 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 2H2F10 |
Calculated MW | 48kDa |
Dilution | ELISA (1:10000), IHC-P (1:200), WB (1:500-1:2000) |
Gene ID | 55359 |
---|---|
Other Names | Tyrosine-protein kinase STYK1, 2.7.10.2, Novel oncogene with kinase domain, Protein PK-unique, Serine/threonine/tyrosine kinase 1, STYK1, NOK |
Target/Specificity | Ni-NTA purified truncated recombinant STYK1-His is expressed in E. Coli strain BL21 (DE3) |
Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
Precautions | STYK1 Antibody (clone 2H2F10) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | STYK1 |
---|---|
Synonyms | NOK |
Function | Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). |
Cellular Location | Membrane; Single-pass membrane protein |
Tissue Location | Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers |
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Provided below are standard protocols that you may find useful for product applications.
Background
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
References
Ye X.,et al.Mol. Biol. Rep. 30:91-96(2003).
Liu L.,et al.Cancer Res. 64:3491-3499(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Scherer S.E.,et al.Nature 440:346-351(2006).
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