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IL13 Antibody (clone A130D 12G5 1E4)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E, FC |
|---|---|
| Primary Accession | P35225 |
| Reactivity | Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | A130D 12G5 1E4 |
| Calculated MW | 16kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 3596 |
|---|---|
| Other Names | Interleukin-13, IL-13, IL13, NC30 |
| Target/Specificity | Recognizes recombinant and native rat IL-13. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | IL13 Antibody (clone A130D 12G5 1E4) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IL13 |
|---|---|
| Synonyms | NC30 |
| Function | Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:8096327, PubMed:8097324). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (PubMed:7903680, PubMed:8759755). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Also functions on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils (PubMed:8639787). Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed:9013879). Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed:21622864). |
| Cellular Location | Secreted. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
References
Minty A.J.,et al.Nature 362:248-250(1993).
McKenzie A.N.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:3735-3739(1993).
Smirnov D.V.,et al.Gene 155:277-281(1995).
Dolganov G.,et al.Blood 87:3316-3326(1996).
Schmutz J.,et al.Nature 431:268-274(2004).
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