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SELPLG / PSGL-1 / CD162 Antibody (clone HECA-452)
Rat Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, FC |
|---|---|
| Primary Accession | Q14242 |
| Reactivity | Human, Mouse |
| Host | Rat |
| Clonality | Monoclonal |
| Clone Names | HECA-452 |
| Calculated MW | 43kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 6404 |
|---|---|
| Other Names | P-selectin glycoprotein ligand 1, PSGL-1, Selectin P ligand, CD162, SELPLG |
| Reconstitution & Storage | +4°C, avoid freezing |
| Precautions | SELPLG / PSGL-1 / CD162 Antibody (clone HECA-452) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SELPLG |
|---|---|
| Function | A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Expressed on neutrophils, monocytes and most lymphocytes |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
References
Veldman G.M.,et al.J. Biol. Chem. 270:16470-16475(1995).
Sako D.,et al.Cell 75:1179-1186(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Moore K.L.,et al.J. Biol. Chem. 269:23318-23327(1994).
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