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CRYM Antibody (clone 6B3)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q14894 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6B3 |
| Calculated MW | 34kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 1428 |
|---|---|
| Other Names | Ketimine reductase mu-crystallin, 1.5.1.25, NADP-regulated thyroid-hormone-binding protein, CRYM, THBP |
| Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
| Precautions | CRYM Antibody (clone 6B3) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CRYM (HGNC:2418) |
|---|---|
| Function | Catalyzes the NAD(P)H-dependent reduction of imine double bonds of a number of cyclic ketimine substrates, including sulfur- containing cyclic ketimines (PubMed:21332720, PubMed:25931162). Under physiological conditions, it efficiently catalyzes delta(1)- piperideine-2-carboxylate (P2C) and delta(1)-pyrroline-2-carboxylate (Pyr2C) reduction, suggesting a central role in lysine and glutamate metabolism (PubMed:25931162). Additional substrates are delta(2)- thiazoline-2-carboxylate (T2C), 3,4-dehydrothiomorpholine-3-carboxylate (AECK), and (R)-lanthionine ketimine (LK) that is reduced at very low rate compared to other substrates (PubMed:25931162). Also catalyzes the NAD(P)H-dependent reduction of (S)-cystathionine ketimine (CysK) (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in neural tissues, muscle and kidney (PubMed:1384048). Expressed in the inner ear (PubMed:12471561) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.
References
Segovia L.,et al.Mol. Vis. 3:9-9(1997).
Vie M.-P.,et al.Mol. Endocrinol. 11:1728-1736(1997).
Sperbeck S.J.,et al.Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
Loftus B.J.,et al.Genomics 60:295-308(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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