SLC44A2 / CTL2 Antibody (clone 3D11)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q8IWA5 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 3D11 |
Calculated MW | 80kDa |
Dilution | IHC-P (10 µg/ml) |
Gene ID | 57153 |
---|---|
Other Names | Choline transporter-like protein 2, Solute carrier family 44 member 2, SLC44A2, CTL2 |
Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
Precautions | SLC44A2 / CTL2 Antibody (clone 3D11) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC44A2 (HGNC:17292) |
---|---|
Synonyms | CTL2 |
Function | [Isoform 1]: Choline/H+ antiporter, mainly in mitochodria (PubMed:10677542, PubMed:20665236, PubMed:33789160, PubMed:23651124). Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway (PubMed:33789160). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Note=Mainly expressed in mitochondria {ECO:0000250|UniProtKB:B4F795} |
Tissue Location | Present in supporting cells of the inner ear (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Isoform 1, but not isoform 3, exhibits some choline transporter activity.
References
O'Regan S.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(2000).
Nair T.S.,et al.J. Neurosci. 24:1772-1779(2004).
Santoso S.S.,et al.Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
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