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PRPK / TP53RK Antibody (clone 4B9-1H3)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q96S44 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4B9-1H3 |
| Calculated MW | 28kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 112858 |
|---|---|
| Other Names | TP53-regulating kinase, 2.7.11.1, Atypical serine/threonine protein kinase TP53RK, EKC/KEOPS complex subunit TP53RK, 3.6.-.-, Nori-2, p53-related protein kinase, TP53RK, C20orf64, PRPK |
| Reconstitution & Storage | Store at -20°C. Aliquot to avoid freeze/thaw cycles. |
| Precautions | PRPK / TP53RK Antibody (clone 4B9-1H3) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TP53RK (HGNC:16197) |
|---|---|
| Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Highly expressed in testis. Weakly expressed in heart kidney and spleen. |
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Background
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.
References
Abe Y.,et al.J. Biol. Chem. 276:44003-44011(2001).
Abe Y.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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