CCT2 / CCT Beta Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | P78371 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 57kDa |
Dilution | IHC-P (10 µg/ml), WB (1:500-1:3000), |
Gene ID | 10576 |
---|---|
Other Names | T-complex protein 1 subunit beta, TCP-1-beta, CCT-beta, CCT2, 99D8.1, CCTB |
Target/Specificity | Human TCP1 beta. Predicted cross-reactivity based on amino acid sequence homology: mouse (97%), rat (97%), rabbit (100%), bovine (98%), pig (100%), zebrafish (87%). |
Reconstitution & Storage | Aliquot and store at -20°C. Minimize freezing and thawing. |
Precautions | CCT2 / CCT Beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CCT2 |
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Synonyms | 99D8.1, CCTB |
Function | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). |
Cellular Location | Cytoplasm. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
References
Won K.-A.,et al.Mol. Cell. Biol. 18:7584-7589(1998).
Xin Y.,et al.Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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