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>   home   >   Products   >   Primary Antibodies   >   SLC5A3 / SMIT2 Antibody (aa221-270)   

SLC5A3 / SMIT2 Antibody (aa221-270)

Rabbit Polyclonal Antibody

     
  • WB - SLC5A3 / SMIT2 Antibody (aa221-270) ALS13668
    Western blot of extracts from HUVEC cells, using SLC5A3 Antibody.
    detail
  • IHC - SLC5A3 / SMIT2 Antibody (aa221-270) ALS13668
    Anti-SLC5A3 antibody IHC of human prostate.
    detail
  • IHC - SLC5A3 / SMIT2 Antibody (aa221-270) ALS13668
    Anti-SLC5A3 antibody IHC of human uterus.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P53794
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 79664 Da
Dilution ELISA (1:10000), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Other Names Sodium/myo-inositol cotransporter, Na(+)/myo-inositol cotransporter, Sodium/myo-inositol transporter 1, SMIT1, Solute carrier family 5 member 3, SLC5A3
Target/Specificity SLC5A3 Antibody detects endogenous levels of total SLC5A3 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsSLC5A3 / SMIT2 Antibody (aa221-270) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC5A3 (HGNC:11038)
Function Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (PubMed:24595108, PubMed:28793216). Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (PubMed:24595108) (By similarity). Associates with KCNQ2- KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (PubMed:28793216). Provides myo- inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide- dependent ion channels and Ca(2+) signaling upon osmotic stress (PubMed:27217553).
Cellular Location Apical cell membrane {ECO:0000250|UniProtKB:Q9JKZ2}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9JKZ2}; Multi-pass membrane protein. Note=Colocalizes with KCNQ1 at the apical membrane of choroid plexus epithelium. {ECO:0000250|UniProtKB:Q9JKZ2}
Volume 50 µl
Citations (0)
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$ 467.50
Cat# ALS13668
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