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ST14 / Matriptase Antibody (aa10-59)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q9Y5Y6 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 95kDa |
| Dilution | ELISA (1:10000), IF (1:100-1:500), IHC-P (10 µg/ml), WB (1:500-1:1000) , |
| Gene ID | 6768 |
|---|---|
| Other Names | Suppressor of tumorigenicity 14 protein, 3.4.21.109, Matriptase, Membrane-type serine protease 1, MT-SP1, Prostamin, Serine protease 14, Serine protease TADG-15, Tumor-associated differentially-expressed gene 15 protein, ST14, PRSS14, SNC19, TADG15 |
| Target/Specificity | ST14 Antibody detects endogenous levels of total ST14 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | ST14 / Matriptase Antibody (aa10-59) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ST14 |
|---|---|
| Synonyms | PRSS14, SNC19, TADG15 |
| Function | Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (PubMed:10373424). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (PubMed:18843291). Proteolytically cleaves and therefore activates TMPRSS13 (PubMed:28710277). |
| Cellular Location | Membrane; Single-pass type II membrane protein |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.
References
Lin C.Y.,et al.J. Biol. Chem. 274:18231-18236(1999).
Takeuchi T.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:11054-11061(1999).
Yamaguchi N.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Tanimoto H.,et al.Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
Cao J.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
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