MYRIP Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q8NFW9 |
Reactivity | Human, Monkey |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 96kDa |
Dilution | ELISA (1:64000), IHC-P (3.75 µg/ml), WB (1:64000) |
Gene ID | 25924 |
---|---|
Other Names | Rab effector MyRIP, Exophilin-8, Myosin-VIIa- and Rab-interacting protein, Synaptotagmin-like protein lacking C2 domains C, SlaC2-c, Slp homolog lacking C2 domains c, MYRIP, SLAC2C |
Target/Specificity | Human MYRIP. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | MYRIP Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MYRIP |
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Synonyms | SLAC2C |
Function | Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8K3I4}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TNY7} Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q7TNY7} Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments {ECO:0000250|UniProtKB:Q7TNY7} |
Tissue Location | Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis |
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Background
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity).
References
El-Amraoui A.,et al.EMBO Rep. 3:463-470(2002).
Fukuda M.,et al.J. Biol. Chem. 277:43096-43103(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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