NTSR1 / NTR Antibody (aa181-230)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC-P, E |
---|---|
Primary Accession | P30989 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 46kDa |
Dilution | ELISA (1:1000), IHC-P (5 µg/ml), WB (1:500-1:1000) |
Gene ID | 4923 |
---|---|
Other Names | Neurotensin receptor type 1, NT-R-1, NTR1, High-affinity levocabastine-insensitive neurotensin receptor, NTRH, NTSR1, NTRR |
Target/Specificity | NTR1 Antibody detects endogenous levels of total NTR1 protein. |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | NTSR1 / NTR Antibody (aa181-230) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NTSR1 |
---|---|
Synonyms | NTRR |
Function | G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:21725197, PubMed:23140271, PubMed:8381365). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Membrane raft. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts |
Tissue Location | Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain. |

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Provided below are standard protocols that you may find useful for product applications.
Background
G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.
References
Vita N.,et al.FEBS Lett. 317:139-142(1993).
Kopatz S.A.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
Deloukas P.,et al.Nature 414:865-871(2001).
Swift S.L.,et al.Cancer Res. 70:347-356(2010).
Heakal Y.,et al.Cancer Biol. Ther. 12:427-435(2011).

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