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CDKN2A / p16INK4a Antibody (clone 1E12E10)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P42771 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Monoclonal [1E12E10] |
| Clone Names | 1E12E10 |
| Calculated MW | 17kDa |
| Dilution | ELISA (1:10000), IHC-P (5 µg/ml), WB (1:500-1:2000) |
| Gene ID | 1029 |
|---|---|
| Other Names | Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3, Cyclin-dependent kinase 4 inhibitor A, CDK4I, Multiple tumor suppressor 1, MTS-1, p16-INK4a, p16-INK4, p16INK4A, CDKN2A, CDKN2, MTS1 |
| Target/Specificity | Targets P16. Shows reactivity with Human, Mouse, and Rat samples. |
| Format | PBS with 0.1% sodium azide and 1% BSA. |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | CDKN2A / p16INK4a Antibody (clone 1E12E10) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDKN2A (HGNC:1787) |
|---|---|
| Synonyms | CDKN2, MTS1 |
| Function | Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific |
| Volume | Array |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
References
Serrano M.,et al.Nature 366:704-707(1993).
Robertson K.D.,et al.Oncogene 18:3810-3820(1999).
Kitagawa Y.,et al.J. Biol. Chem. 277:46289-46297(2002).
Lin Y.C.,et al.Oncogene 26:7017-7027(2007).
Humphray S.J.,et al.Nature 429:369-374(2004).
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