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SPRY1 / Sprouty 1 Antibody (clone 3H4)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O43609 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 3H4 |
| Calculated MW | 35kDa |
| Dilution | IHC-P (5 µg/ml), WB (1:500-1:1000), |
| Gene ID | 10252 |
|---|---|
| Other Names | Protein sprouty homolog 1, Spry-1, SPRY1 |
| Target/Specificity | Human SPRY1 |
| Reconstitution & Storage | For long term, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SPRY1 / Sprouty 1 Antibody (clone 3H4) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SPRY1 |
|---|---|
| Function | Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). |
| Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor) |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
References
Wang L.,et al.Int. J. Mol. Med. 12:783-787(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Raya A.,et al.Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
Hacohen N.,et al.Cell 92:253-263(1998).
Bienvenut W.V.,et al.Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
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