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SLC11A2 / DMT1 Antibody (clone 4C6)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P49281 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4C6 |
| Calculated MW | 62kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 4891 |
|---|---|
| Other Names | Natural resistance-associated macrophage protein 2, NRAMP 2, Divalent cation transporter 1, Divalent metal transporter 1, DMT-1, Solute carrier family 11 member 2, SLC11A2, DCT1, DMT1, NRAMP2 |
| Target/Specificity | Human SLC11A2 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | SLC11A2 / DMT1 Antibody (clone 4C6) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC11A2 |
|---|---|
| Synonyms | DCT1, DMT1, NRAMP2 |
| Function | Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:17109629, PubMed:22736759, PubMed:25491917, PubMed:17293870, PubMed:25326704). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (PubMed:17109629, PubMed:22736759, PubMed:25491917, PubMed:17293870, PubMed:25326704). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (PubMed:24448823) (By similarity). Can mediate uncoupled fluxes of either protons or metal ions. |
| Cellular Location | [Isoform 1]: Early endosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Predominantly localizes in early endosomes that underlie the apical membrane of polarized epithelia. [Isoform 3]: Cell membrane |
| Tissue Location | Ubiquitously expressed. Expressed in erythroid progenitors. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.
References
Kishi F.,et al.Mol. Immunol. 34:839-842(1997).
Kishi F.,et al.Biochem. Biophys. Res. Commun. 251:775-783(1998).
Lee P.L.,et al.Blood Cells Mol. Dis. 24:199-215(1998).
Hubert N.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:12345-12350(2002).
Worthington M.T.,et al.Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
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