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STXBP1 / MUNC18-1 Antibody (clone 6D1)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P61764 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6D1 |
| Calculated MW | 68kDa |
| Dilution | IHC-P (5 µg/ml), WB (1:500-1:1000), |
| Gene ID | 6812 |
|---|---|
| Other Names | Syntaxin-binding protein 1, MUNC18-1, N-Sec1, Protein unc-18 homolog 1, Unc18-1, Protein unc-18 homolog A, Unc-18A, p67, STXBP1, UNC18A |
| Target/Specificity | Human STXBP1 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | STXBP1 / MUNC18-1 Antibody (clone 6D1) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STXBP1 |
|---|---|
| Synonyms | UNC18A |
| Function | Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions. |
| Cellular Location | Cytoplasm, cytosol. Membrane; Peripheral membrane protein |
| Tissue Location | Brain and spinal cord. Highly enriched in axons. |
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Provided below are standard protocols that you may find useful for product applications.
Background
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
References
Gengyo-Ando K.,et al.J. Neurosci. 16:6695-6702(1996).
Swanson D.A.,et al.Genomics 48:373-376(1998).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Tian J.H.,et al.J. Biol. Chem. 278:26265-26274(2003).
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