|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:1000), IF (1:100-1:500), IHC-P (10 µg/ml), WB (1:500-1:1000) ,|
|Other Names||Dihydropyrimidinase-related protein 2, DRP-2, Collapsin response mediator protein 2, CRMP-2, N2A3, Unc-33-like phosphoprotein 2, ULIP-2, DPYSL2, CRMP2, ULIP2|
|Target/Specificity||DPYSL2 Antibody detects endogenous levels of total DPYSL2 protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||DPYSL2 / CRMP2 Antibody (aa480-529) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.|
|Cellular Location||Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane. Note=Tightly but non-covalently associated with membranes|
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Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Goshima Y.,et al.Nature 376:509-514(1995).
Hamajima N.,et al.Gene 180:157-163(1996).
Zhou J.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
Kitamura K.,et al.DNA Res. 6:291-297(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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