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TSPO / PBR Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P30536 |
| Reactivity | Human, Mouse |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 19kDa |
| Dilution | ELISA (1:16000), IHC-P (3.75 µg/ml), WB (0.5-1 µg/ml) |
| Gene ID | 706 |
|---|---|
| Other Names | Translocator protein, Mitochondrial benzodiazepine receptor, PKBS, Peripheral-type benzodiazepine receptor, PBR, TSPO, BZRP, MBR |
| Target/Specificity | Mouse TSPO. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | TSPO / PBR Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TSPO |
|---|---|
| Synonyms | BZRP, MBR |
| Function | Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral- type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678). |
| Cellular Location | Mitochondrion membrane; Multi-pass membrane protein |
| Tissue Location | Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides(PubMed:1847678).
References
Riond J.,et al.Eur. J. Biochem. 195:305-311(1991).
Yakovlev A.G.,et al.Gene 155:201-205(1995).
Costa B.,et al.Mol. Pharmacol. 69:37-44(2006).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
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