RAPGEF6 Antibody (clone 2C5)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q8TEU7 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 2C5 |
Calculated MW | 179kDa |
Dilution | IF (40 µg/ml), IHC-P (5 µg/ml), WB (1:500-1:1000) |
Gene ID | 51735 |
---|---|
Other Names | Rap guanine nucleotide exchange factor 6, PDZ domain-containing guanine nucleotide exchange factor 2, PDZ-GEF2, RA-GEF-2, RAPGEF6, PDZGEF2 |
Target/Specificity | Human RAPGEF6 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | RAPGEF6 Antibody (clone 2C5) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RAPGEF6 |
---|---|
Synonyms | PDZGEF2 |
Function | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. |
Cellular Location | Cytoplasm. Cell membrane. Note=Upon binding to M-Ras, it translocates to the plasma membrane |
Tissue Location | Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.
References
Kuiperij H.B.,et al.Biochim. Biophys. Acta 1593:141-149(2003).
Banville D.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Gao X.,et al.J. Biol. Chem. 276:42219-42225(2001).
Schmutz J.,et al.Nature 431:268-274(2004).
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
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