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CXCR3 Antibody (aa161-210)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P49682 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41kDa |
| Dilution | ELISA (1:5000), IHC-P (10 µg/ml), WB (1:500-1:1000) |
| Gene ID | 2833 |
|---|---|
| Other Names | C-X-C chemokine receptor type 3, CXC-R3, CXCR-3, CKR-L2, G protein-coupled receptor 9, Interferon-inducible protein 10 receptor, IP-10 receptor, CD183, CXCR3, GPR9 |
| Target/Specificity | CXCR3 Antibody detects endogenous levels of total CXCR3 protein. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | CXCR3 Antibody (aa161-210) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CXCR3 |
|---|---|
| Synonyms | GPR9 |
| Function | [Isoform 1]: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G- protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. [Isoform 3]: Mediates the activity of CXCL11. |
| Cellular Location | [Isoform 1]: Cell membrane; Multi-pass membrane protein |
| Tissue Location | Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level). |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 3: Mediates the activity of CXCL11.
References
Loetscher M.,et al.J. Exp. Med. 184:963-969(1996).
Lasagni L.,et al.J. Exp. Med. 197:1537-1549(2003).
Petrai I.,et al.Int. J. Biochem. Cell Biol. 40:1764-1774(2008).
Gutierrez J.,et al.Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
Warren C.N.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
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