MYZAP Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF |
---|---|
Primary Accession | P0CAP1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 54206 Da |
Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
Gene ID | 100820829;145781;81488 |
---|---|
Other Names | Myocardial zonula adherens protein, GRINL1A upstream protein, Gup, MYZAP, MYOZAP |
Target/Specificity | Human GCOM1. Multiple isoforms of MYOZAP are known to exist. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | MYZAP Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MYZAP |
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Synonyms | MYOZAP |
Function | Plays a role in cellular signaling via Rho-related GTP- binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity). |
Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5EB94}. Cell membrane {ECO:0000250|UniProtKB:Q5EB94}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q5EB94}; Cytoplasmic side {ECO:0000250|UniProtKB:Q5EB94}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:Q5EB94}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q5EB94}. Cell junction Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin Colocalizes with cortical actin. {ECO:0000250|UniProtKB:Q5EB94} |
Tissue Location | Detected in heart, liver, skeletal muscle, placenta, small intestine, lung, prostate and testis. Expressed in arrector pili muscle (at protein level) (PubMed:29034528) |
Volume | 50 µl |
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