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KCNK13 / THIK-1 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | Q9HB14 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 45kDa |
| Dilution | IHC-P (5 µg/ml), WB (1-2 µg/ml), |
| Gene ID | 56659 |
|---|---|
| Other Names | Potassium channel subfamily K member 13, Tandem pore domain halothane-inhibited potassium channel 1, THIK-1, KCNK13 |
| Target/Specificity | Human KCNK13. KCNK13 antibody is predicted to not cross-react with other KCNK protein family members. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | KCNK13 / THIK-1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNK13 {ECO:0000303|PubMed:24163367, ECO:0000312|HGNC:HGNC:6275} |
|---|---|
| Function | K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals (PubMed:24163367, PubMed:25148687, PubMed:30472253, PubMed:38409076). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:25148687). Contributes most of K(+) currents at the plasma membrane of resting microglia. Maintains a depolarized membrane potential required for proper ramified microglia morphology and phagocytosis, selectively mediating microglial pruning of presynaptic compartments at hippocampal excitatory synapses (PubMed:38409076). Upon local release of ATP caused by neuronal injury or infection, it is potentiated by P2RY12 and P2RX7 receptor signaling and contributes to ATP-triggered K(+) efflux underlying microglial NLRP3 inflammasome assembly and IL1B release (By similarity) (PubMed:38409076). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in microglia (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Potassium channel displaying weak inward rectification in symmetrical K(+) solution.
References
Rajan S.,et al.J. Biol. Chem. 276:7302-7311(2001).
Gierten J.,et al.Br. J. Pharmacol. 154:1680-1690(2008).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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