ARRDC3 Antibody (aa365-414)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q96B67 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 46kDa |
Dilution | ELISA (1:20000), IHC-P (5 µg/ml), WB (1:500-1:1000) |
Gene ID | 57561 |
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Other Names | Arrestin domain-containing protein 3, TBP-2-like inducible membrane protein, TLIMP, ARRDC3, KIAA1376 |
Target/Specificity | ARRDC3 Antibody detects endogenous levels of total ARRDC3 protein. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | ARRDC3 Antibody (aa365-414) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ARRDC3 |
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Synonyms | KIAA1376 |
Function | Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550). |
Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side Lysosome Endosome Early endosome. Note=Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis (PubMed:16269462, PubMed:23208550, PubMed:20559325) |
Tissue Location | Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea (PubMed:16269462, PubMed:21982743). Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow (PubMed:16269462). Strong expression in differentiated adipocytes compared to preadipocytes (PubMed:16269462). Detected in omental fat and subcutaneous fat tissue (PubMed:21982743) |
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Provided below are standard protocols that you may find useful for product applications.
References
Nagase T.,et al.DNA Res. 7:65-73(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Oka S.,et al.Endocrinology 147:733-743(2006).
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