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HAMP / Hepcidin Antibody (N-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | P81172 |
| Reactivity | Human, Monkey |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 9kDa |
| Dilution | ELISA (1:16000), IHC-P (3.75 µg/ml), |
| Gene ID | 57817 |
|---|---|
| Other Names | Hepcidin, Liver-expressed antimicrobial peptide 1, LEAP-1, Putative liver tumor regressor, PLTR, Hepcidin-25, Hepc25, Hepcidin-20, Hepc20, HAMP, HEPC, LEAP1 |
| Target/Specificity | Human HAMP / Hepcidin. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | HAMP / Hepcidin Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HAMP (HGNC:15598) |
|---|---|
| Synonyms | HEPC, LEAP1 |
| Function | Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342). Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005). |
| Cellular Location | Secreted. |
| Tissue Location | Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine and blood (PubMed:11034317). Expressed by hepatocytes (PubMed:15124018). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005).
References
Park C.H.,et al.J. Biol. Chem. 276:7806-7810(2001).
Krause A.,et al.FEBS Lett. 480:147-150(2000).
Jung J.-W.,et al.Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Grimwood J.,et al.Nature 428:529-535(2004).
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