LAIR1 / CD305 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q6GTX8 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 31kDa |
Dilution | ELISA (1:1000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml) |
Gene ID | 3903 |
---|---|
Other Names | Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, CD305, LAIR1, CD305 |
Target/Specificity | Human LAIR1 / LAIR-1. This antibody is expected to recognize both isoforms (NP_002278.1; NP_068352.1). |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | LAIR1 / CD305 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LAIR1 |
---|---|
Synonyms | CD305 |
Function | Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T- cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. |
Cellular Location | Cell membrane; Single-pass type I membrane protein |
Tissue Location | Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection. |
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Background
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down- regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
References
Meyaard L.,et al.Immunity 7:283-290(1997).
Meyaard L.,et al.J. Immunol. 162:5800-5804(1999).
Xu M.-J.,et al.J. Biol. Chem. 275:17440-17446(2000).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Poggi A.,et al.Eur. J. Immunol. 28:2086-2091(1998).
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