SOX3 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P41225 |
Reactivity | Human, Mouse, Rabbit, Monkey |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 45kDa |
Dilution | ELISA (1:8000), IHC-P (3.75 µg/ml), WB (0.5-1.5 µg/ml) |
Gene ID | 6658 |
---|---|
Other Names | Transcription factor SOX-3, SOX3 |
Target/Specificity | Human SOX3. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | SOX3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SOX3 |
---|---|
Function | Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity).
References
Stevanovic M.,et al.Hum. Mol. Genet. 2:2013-2018(1993).
Gorry M.C.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Ross M.T.,et al.Nature 434:325-337(2005).
Denny P.,et al.Nucleic Acids Res. 20:2887-2887(1992).
Sutton E.,et al.J. Clin. Invest. 121:328-341(2011).
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