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ARHGDIG / RHOGDI-3 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q99819 |
| Reactivity | Human, Monkey, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 25kDa |
| Dilution | ELISA (1:16000), IHC-P (3.75 µg/ml), WB (0.5-2 µg/ml) |
| Gene ID | 398 |
|---|---|
| Other Names | Rho GDP-dissociation inhibitor 3, Rho GDI 3, Rho-GDI gamma, ARHGDIG |
| Target/Specificity | Human ARHGDIG. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | ARHGDIG / RHOGDI-3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARHGDIG |
|---|---|
| Function | Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Primarily expressed in pancreas and brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.
References
Adra C.N.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:4279-4284(1997).
Adra C.N.,et al.Genomics 53:104-109(1998).
Hayashi A.,et al.Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Daniels R.J.,et al.Hum. Mol. Genet. 10:339-352(2001).
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