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SLC25A21 / ODC1 Antibody (aa134-183)

Rabbit Polyclonal Antibody

     
  • WB - SLC25A21 / ODC1 Antibody (aa134-183) ALS15503
    Western blot of extracts from HepG2 cells, using SLC25A21 Antibody.
    detail
  • IHC - SLC25A21 / ODC1 Antibody (aa134-183) ALS15503
    Anti-SLC25A21 / ODC antibody IHC of human spleen.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9BQT8
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 33kDa
Dilution ELISA (1:40000), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 89874
Other Names Mitochondrial 2-oxodicarboxylate carrier, Solute carrier family 25 member 21, SLC25A21, ODC
Target/Specificity SLC25A21 Antibody detects endogenous levels of total SLC25A21 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsSLC25A21 / ODC1 Antibody (aa134-183) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC25A21
Synonyms ODC
Function Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism (PubMed:11083877). Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2- aminohexanedioate), oxaloacetate, and citrate (PubMed:11083877). Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle (Probable).
Cellular Location Mitochondrion inner membrane; Multi-pass membrane protein
Tissue Location Expressed in placenta, gall bladder and colon.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.

References

Fiermonte G.,et al.J. Biol. Chem. 276:8225-8230(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Heilig R.,et al.Nature 421:601-607(2003).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).

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$ 467.50
Cat# ALS15503
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