TNC / Tenascin C Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
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Primary Accession | P24821 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 241kDa |
Dilution | IHC-P (10 µg/ml) |
Gene ID | 3371 |
---|---|
Other Names | Tenascin, TN, Cytotactin, GMEM, GP 150-225, Glioma-associated-extracellular matrix antigen, Hexabrachion, JI, Myotendinous antigen, Neuronectin, Tenascin-C, TN-C, TNC, HXB |
Target/Specificity | Human TNC / Tenascin C |
Reconstitution & Storage | Aliquot and freeze at -20° C. Avoid freeze-thaw cycles. |
Precautions | TNC / Tenascin C Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TNC |
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Synonyms | HXB |
Function | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha- V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). |
Cellular Location | Secreted, extracellular space, extracellular matrix |
Tissue Location | Detected in fibroblasts (at protein level). |
Volume | 50 µl |
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Background
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
References
Nies D.E.,et al.J. Biol. Chem. 266:2818-2823(1991).
Siri A.,et al.Nucleic Acids Res. 19:525-531(1991).
Gulcher J.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:9438-9442(1991).
Gherzi R.,et al.J. Biol. Chem. 270:3429-3434(1995).
Humphray S.J.,et al.Nature 429:369-374(2004).
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