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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VPS13B Antibody (N-Terminus)   

VPS13B Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - VPS13B Antibody (N-Terminus) ALS15635
    Anti-VPS13B antibody IHC staining of human skin.
    detail
  • IF - VPS13B Antibody (N-Terminus) ALS15635
    Immunofluorescence of COH1 in human brain tissue with COH1 antibody at 20 ug/ml.
    detail
  • WB - VPS13B Antibody (N-Terminus) ALS15635
    Western blot analysis of COH1 in SK-N-SH cell lysate with COH1 antibody at (A) 1 and (B) 2 ug/ml.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q7Z7G8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 449kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 157680
Other Names Vacuolar protein sorting-associated protein 13B, Cohen syndrome protein 1, VPS13B, CHS1, COH1, KIAA0532
Target/Specificity Human VPS13B. At least five alternatively spliced transcript variants have been observed. COH1 detects two isoforms.
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsVPS13B Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VPS13B
Synonyms CHS1, COH1, KIAA0532
Function Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3- phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:30962439, PubMed:24334764, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity).
Cellular Location Recycling endosome membrane {ECO:0000250|UniProtKB:Q80TY5}; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q80TY5}; Peripheral membrane protein. Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Endoplasmic reticulum- Golgi intermediate compartment membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein. Note=Localizes to proacrosomal and acrosomal vesicles and not the Golgi apparatus during acrosome formation. {ECO:0000250|UniProtKB:Q80TY5}
Tissue Location Widely expressed (PubMed:12730828). There is apparent differential expression of different transcripts (PubMed:12730828, PubMed:19006247). In fetal brain, lung, liver, and kidney, two transcripts of 2 and 5 kb are identified (PubMed:12730828) These transcripts are also seen in all adult tissues analyzed (PubMed:12730828). A larger transcript (12-14 kb) is expressed in prostate, testis, ovary, and colon in the adult (PubMed:12730828) Expression is very low in adult brain tissue (PubMed:12730828) Expressed in peripheral blood lymphocytes (PubMed:33025479). Isoform 1 and isoform 2 are expressed in brain and retina (PubMed:12730828, PubMed:19006247). Isoform 2 is expressed ubiquitously (PubMed:12730828, PubMed:19006247).
Research Areas
Citations (0)
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Background

May be involved in protein sorting in post Golgi membrane traffic.

References

Kolehmainen J.,et al.Am. J. Hum. Genet. 72:1359-1369(2003).
Velayos-Baeza A.,et al.Genomics 84:536-549(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Nagase T.,et al.DNA Res. 5:31-39(1998).

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Discontinued
Cat# ALS15635
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