MYST1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q9H7Z6 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 52kDa |
Dilution | IHC-P (10 µg/ml) |
Gene ID | 84148 |
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Other Names | Histone acetyltransferase KAT8, 2.3.1.48, Lysine acetyltransferase 8, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1, MYST-1, hMOF, KAT8, MOF, MYST1 |
Target/Specificity | Human MYST1 |
Reconstitution & Storage | Aliquot and freeze at -20° C. Avoid freeze-thaw cycles. |
Precautions | MYST1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KAT8 |
---|---|
Synonyms | MOF, MYST1 |
Function | Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126). May influence the function of ATM (PubMed:15923642). As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026). That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026). Can also acetylate TP53/p53 at 'Lys-120'. |
Cellular Location | Nucleus. Chromosome |
Volume | 100 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Borrow J.,et al.Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Neal K.C.,et al.Biochim. Biophys. Acta 1490:170-174(2000).
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