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> home > Products > Primary Antibodies > Signal Transduction > PLD4 / Phospholipase D4 Antibody (aa457-506)
PLD4 / Phospholipase D4 Antibody (aa457-506)
Rabbit Polyclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q96BZ4 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 56kDa |
| Dilution | ELISA (1:5000), IHC-P (5 µg/ml), WB (1:500-1:1000) |
| Gene ID | 122618 |
|---|---|
| Other Names | Phospholipase D4, PLD 4, 3.1.4.4, Choline phosphatase 4, Phosphatidylcholine-hydrolyzing phospholipase D4, PLD4, C14orf175 |
| Target/Specificity | PLD4 Antibody detects endogenous levels of total PLD4 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | PLD4 / Phospholipase D4 Antibody (aa457-506) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLD4 |
|---|---|
| Synonyms | C14orf175 |
| Function | 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia. |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BG07}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8BG07}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q8BG07}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8BG07}. Nucleus {ECO:0000250|UniProtKB:Q8BG07}. Early endosome {ECO:0000250|UniProtKB:Q8BG07}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q8BG07}. Note=Activation of microglia induces translocation of PLD4 from the nucleus to the phagosomes {ECO:0000250|UniProtKB:Q8BG07} |
| Volume | 50 µl |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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$ 467.50
Cat# ALS15743
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