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SS18 Antibody (Ala7)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q15532 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 46kDa |
| Dilution | IHC-P (5 µg/ml), WB (1:500-1:1000), |
| Gene ID | 6760 |
|---|---|
| Other Names | Protein SSXT, Protein SYT, Synovial sarcoma translocated to X chromosome protein, SS18, SSXT, SYT |
| Target/Specificity | SYT (A7) pAb detects endogenous levels of SYT protein. |
| Reconstitution & Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Precautions | SS18 Antibody (Ala7) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SS18 |
|---|---|
| Synonyms | SSXT, SYT |
| Function | Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). |
| Cellular Location | Nucleus. |
| Tissue Location | Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT- SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.
References
Clark J.,et al.Nat. Genet. 7:502-508(1994).
Brodin B.,et al.Gene 268:173-182(2001).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Fligman I.,et al.Am. J. Pathol. 147:1592-1599(1995).
de Bruijn D.R.,et al.Oncogene 20:3281-3289(2001).
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