TIAL1 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q01085 |
Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Chicken, Horse, Xenopus, Bovine, Dog |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 42kDa |
Dilution | ELISA (1:64000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml) |
Gene ID | 7073 |
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Other Names | Nucleolysin TIAR, TIA-1-related protein, TIAL1 |
Target/Specificity | Human TIAL1. This antibody is expected to recognize both isoforms (NP_003243.1; NP_001029097.1). |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | TIAL1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TIAL1 |
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Function | RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (PubMed:1326761, PubMed:8576255, PubMed:17488725, PubMed:10613902). Shows a preference for uridine-rich RNAs (PubMed:8576255). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725). Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (PubMed:10613902). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1326761). May be involved in apoptosis (PubMed:1326761). |
Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:P70318}. Cytolytic granule. Cytoplasm, Stress granule Note=Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity) Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:10613902). {ECO:0000250|UniProtKB:P70318, ECO:0000269|PubMed:10613902} |
Tissue Location | Expressed in brain, heart, kidney, lung and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
References
Kawakami A.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:8681-8685(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Daub H.,et al.Mol. Cell 31:438-448(2008).
Choudhary C.,et al.Science 325:834-840(2009).
Reinhardt H.C.,et al.Mol. Cell 40:34-49(2010).
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