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SSB / La Antibody (clone 1E11)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, IP, FC |
|---|---|
| Primary Accession | P05455 |
| Reactivity | Human, Mouse, Rat, Monkey, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 1E11 |
| Calculated MW | 47kDa |
| Dilution | Flo (1:100), IF (1:50-1:100), IHC-P (10 µg/ml), WB (1:1000-1:2000) , |
| Gene ID | 6741 |
|---|---|
| Other Names | Lupus La protein, La autoantigen, La ribonucleoprotein, Sjoegren syndrome type B antigen, SS-B, SSB |
| Target/Specificity | Human SSB / La |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | SSB / La Antibody (clone 1E11) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SSB |
|---|---|
| Function | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES- mediated translation (PubMed:12384597). |
| Cellular Location | Nucleus. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.
References
Chan E.K.L.,et al.Nucleic Acids Res. 17:2233-2244(1989).
Chambers J.C.,et al.J. Biol. Chem. 263:18043-18051(1988).
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).
Hillier L.W.,et al.Nature 434:724-731(2005).
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