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PCMT1 Antibody (aa10-227)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC |
|---|---|
| Primary Accession | P22061 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 25kDa |
| Dilution | ICC (1:100-1:1000), IHC-P (7.5 µg/ml), WB (1:500-1:3000) |
| Gene ID | 5110 |
|---|---|
| Other Names | Protein-L-isoaspartate(D-aspartate) O-methyltransferase, PIMT, 2.1.1.77, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl/D-aspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PCMT1 |
| Target/Specificity | Human PCMT1 |
| Reconstitution & Storage | Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
| Precautions | PCMT1 Antibody (aa10-227) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PCMT1 |
|---|---|
| Function | Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L- asparaginyl residues in aging peptides and proteins (PubMed:3167043, PubMed:6469980). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity). |
| Cellular Location | Cytoplasm, cytosol. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl- terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity).
References
Ingrosso D.,et al.J. Biol. Chem. 264:20131-20139(1989).
Maclaren D.C.,et al.Biochem. Biophys. Res. Commun. 185:277-283(1992).
Takeda R.,et al.J. Biochem. 117:683-685(1995).
Shirasawa T.,et al.Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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