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SLC16A2 / MCT8 Antibody (aa93-142)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P36021 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 60kDa |
| Dilution | ELISA (1:10000), IHC-P (5 µg/ml), WB (1:500-1:1000) |
| Gene ID | 6567 |
|---|---|
| Other Names | Monocarboxylate transporter 8, MCT 8, Monocarboxylate transporter 7, MCT 7, Solute carrier family 16 member 2, X-linked PEST-containing transporter, SLC16A2, MCT8, XPCT |
| Target/Specificity | SLC16A2 Antibodyantibody detects endogenous levels of SLC16A2. |
| Reconstitution & Storage | Store at -20°C. |
| Precautions | SLC16A2 / MCT8 Antibody (aa93-142) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC16A2 |
|---|---|
| Function | Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3- diiodothyronine (3,3'-T2) (PubMed:16887882, PubMed:18337592, PubMed:20628049, PubMed:23550058, PubMed:26426690, PubMed:27805744, PubMed:31436139). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable) (PubMed:28526555). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in liver and heart (PubMed:7981683). In adult brain tissue expression is largely confined to endothelial cells of the blood-brain barrier (at protein level) (PubMed:18687783, PubMed:32143555). |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity).
References
Lafreniere R.G.,et al.Hum. Mol. Genet. 3:1133-1140(1994).
Kim D.,et al.Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
Ross M.T.,et al.Nature 434:325-337(2005).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
Visser W.E.,et al.Endocrinology 150:5163-5170(2009).
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