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TICRR Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q7Z2Z1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 211kDa |
| Dilution | IF (20 µg/ml), IHC-P (5 µg/ml), WB (1-2 µg/ml) |
| Gene ID | 90381 |
|---|---|
| Other Names | Treslin, TopBP1-interacting checkpoint and replication regulator, TopBP1-interacting, replication-stimulating protein, TICRR, C15orf42 |
| Target/Specificity | TICRR antibody is human specific. At least two isoforms of TICRR are known to exist. |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TICRR Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TICRR |
|---|---|
| Synonyms | C15orf42 |
| Function | Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre- replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. |
| Cellular Location | Nucleus. Note=Associates with chromatin |
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Provided below are standard protocols that you may find useful for product applications.
Background
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre- initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
References
Kumagai A.,et al.Cell 140:349-359(2010).
Zody M.C.,et al.Nature 440:671-675(2006).
Stevens M.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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