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ABCB1 / MDR1 / P Glycoprotein Antibody (clone 6H2)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P08183 |
| Other Accession | 5243 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone Names | 6H2 |
| Calculated MW | 141479 Da |
| Dilution | IHC-P (10 µg/ml), WB (1:1000), |
| Gene ID | 5243 |
|---|---|
| Other Names | ABCB1, ABC20, Abcb1b, CLCS, Colchicin sensitivity, CD243, Doxorubicin resistance, IBD13, gp170, MDR1, Multidrug resistance protein 1, P glycoprotein, P-glycoprotein 1, P-GP, CD243 antigen, PGY1 |
| Target/Specificity | Human ABCB1 / MDR1 |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
| Precautions | ABCB1 / MDR1 / P Glycoprotein Antibody (clone 6H2) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ABCB1 (HGNC:40) |
|---|---|
| Synonyms | MDR1, PGY1 |
| Function | Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218, PubMed:35970996). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D- glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug- resistant cells (PubMed:2897240, PubMed:9038218, PubMed:35970996). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441} Apical cell membrane. Cytoplasm Note=ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm). Localized to the apical membrane of enterocytes (PubMed:28408210). |
| Tissue Location | Expressed in small intestine (PubMed:28408210). Expressed in liver, kidney and brain. |
| Volume | 250 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
References
Chen C.-J.,et al.Cell 47:381-389(1986).
Chen C.-J.,et al.J. Biol. Chem. 265:506-514(1990).
Chen G.,et al.J. Biol. Chem. 272:5974-5982(1997).
Jiang Y.,et al.Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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