AGPAT3 Antibody (aa121-170)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q9NRZ7 |
Other Accession | 56894 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 43381 Da |
Dilution | ELISA (1:40000), IHC-P (10 µg/ml), WB (1:500 - 1:1000), |
Gene ID | 56894 |
---|---|
Other Names | AGPAT3, 1-AGP acyltransferase 3, 1-AGPAT 3, LPAAT3, LPAAT-gamma, LPAAT-GAMMA1 |
Target/Specificity | AGPAT3 Antibody detects endogenous levels of total AGPAT3 protein. |
Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
Precautions | AGPAT3 Antibody (aa121-170) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | AGPAT3 |
---|---|
Synonyms | LPAAT3 |
Function | Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor (By similarity). Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope |
Tissue Location | Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA.
References
Leung D.W.,et al.Front. Biosci. 6:D944-D953(2001).
Nagamine K.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Hattori M.,et al.Nature 405:311-319(2000).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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