ABHD6 Antibody (aa231-280)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q9BV23 |
Other Accession | 57406 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 38331 Da |
Dilution | ELISA (1:20000), IF (1:100 - 1:500), IHC-P (10 µg/ml), WB (1:500 - 1:1000), |
Gene ID | 57406 |
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Other Names | ABHD6, Monoacylglycerol lipase ABHD6, Lipase protein |
Target/Specificity | ABHD6 Antibody detects endogenous levels of total ABHD6 protein. |
Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
Precautions | ABHD6 Antibody (aa231-280) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ABHD6 (HGNC:21398) |
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Function | Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015). |
Cellular Location | Late endosome membrane {ECO:0000250|UniProtKB:Q8R2Y0}; Single-pass type II membrane protein. Lysosome membrane {ECO:0000250|UniProtKB:Q8R2Y0}; Single-pass type II membrane protein. Mitochondrion membrane {ECO:0000250|UniProtKB:Q8R2Y0}; Single-pass type II membrane protein |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Has 2-arachidonoylglycerol hydrolase activity. May be a regulator of endocannabinoid signaling pathways.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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