TCL / RHOJ Antibody (clone 1D7)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF |
---|---|
Primary Accession | Q9H4E5 |
Other Accession | 57381 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG2a |
Clone Names | 1D7 |
Calculated MW | 23821 Da |
Dilution | IF (1:100), IHC-P (10 µg/ml), WB (1:2000), |
Gene ID | 57381 |
---|---|
Other Names | RHOJ, ARHJ, Ras homolog family member J, TC10-like Rho GTPase, TC10B, RAS-like, family 7, member B, RASL7B, RHOI, Tc10-like GTP-binding protein, TCL |
Target/Specificity | Human TCL / RHOJ |
Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
Precautions | TCL / RHOJ Antibody (clone 1D7) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RHOJ |
---|---|
Function | Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707). Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707). |
Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side Note=Localization to the plasma membrane is regulated by GLUL |
Tissue Location | Specifically expressed in endothelial cells in different tissues, such as brain, heart, lung and liver |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morphology (By similarity).
References
Vignal E.,et al.J. Biol. Chem. 275:36457-36464(2000).
Allen M.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
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