INPP5K / SKIP Antibody (aa183-430)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q9BT40 |
Other Accession | 51763 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 51090 Da |
Dilution | ELISA (1:20000 - 1:80000), IHC-P (10 µg/ml), WB (1:500 - 1:1000), |
Gene ID | 51763 |
---|---|
Other Names | INPP5K, SKIP, PPS |
Target/Specificity | Human INPP5K / SKIP. |
Reconstitution & Storage | PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year. |
Precautions | INPP5K / SKIP Antibody (aa183-430) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | INPP5K (HGNC:33882) |
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Function | Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PubMed:10753883, PubMed:16824732). Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5- trisphosphate (PubMed:10753883). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity). |
Cellular Location | Endoplasmic reticulum. Cytoplasm Note=Following stimulation with EGF, translocates to membrane ruffles (PubMed:12536145, PubMed:26940976). Concentrated at the periphery of the nucleus (PubMed:10753883). |
Tissue Location | Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5- trisphosphate. May negatively regulate assembly of the actin cytoskeleton.
References
Ijuin T.,et al.J. Biol. Chem. 275:10870-10875(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Nussbaum R.L.,et al.Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
Gurung R.,et al.J. Biol. Chem. 278:11376-11385(2003).
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