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HSPA6 Antibody (aa377-628)

Rabbit Polyclonal Antibody

     
  • IHC - HSPA6 Antibody (aa377-628) ALS16902
    Anti-HSPA6 antibody IHC staining of human heart.
    detail
  • ICC - HSPA6 Antibody (aa377-628) ALS16902
    Immunofluorescence of paraformaldehyde-fixed A431 using HSPA6 antibody at 1:200 dilution.
    detail
  • WB - HSPA6 Antibody (aa377-628) ALS16902
    Sample (30 ug of whole cell lysate). A: H1299. 7.5% SDS PAGE. HSPA6 antibody diluted at 1:1000
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC
Primary Accession P17066
Other Accession 3310
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 71028 Da
Dilution ICC (1:100 - 1:1000), IHC-P (7.5 µg/ml), WB (1:500 - 1:3000),
Additional Information
Gene ID 3310
Other Names HSPA6, Heat shock 70 kd protein b, Heat shock 70 kDa protein 6, Heat shock 70 kDa protein B, Heat shock 70 kd protein 7, HSP70B
Target/Specificity Human HSPA6
Reconstitution & Storage 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
PrecautionsHSPA6 Antibody (aa377-628) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSPA6
Synonyms HSP70B'
Function Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity).

References

Leung T.K.C.,et al.Biochem. J. 267:125-132(1990).
Gregory S.G.,et al.Nature 441:315-321(2006).
Leung T.K.C.,et al.Genomics 12:74-79(1992).
Schiller P.,et al.J. Mol. Biol. 203:97-105(1988).
Jakobsson M.E.,et al.J. Biol. Chem. 288:27752-27763(2013).

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$ 467.50
Cat# ALS16902
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