LTA / TNF Beta Antibody (aa31-80)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC-P |
---|---|
Primary Accession | P01374 |
Other Accession | 4049 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 22297 Da |
Dilution | IHC-P (10 µg/ml), WB (1:500 - 1:1000), |
Gene ID | 4049 |
---|---|
Other Names | LTA, Lymphotoxin-alpha, LT-alpha, TNFSF1, TNF-beta, TNFB, Tumor necrosis factor beta, LT, TNF Beta |
Target/Specificity | Human TNF Beta |
Reconstitution & Storage | PBS, pH 7.2, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
Precautions | LTA / TNF Beta Antibody (aa31-80) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LTA |
---|---|
Synonyms | TNFB, TNFSF1 |
Function | Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR (PubMed:24248355). Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. |
Cellular Location | Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated |
Volume | 50 µl |

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Provided below are standard protocols that you may find useful for product applications.
Background
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
References
Nedospasov S.A.,et al.Cold Spring Harb. Symp. Quant. Biol. 51:611-624(1986).
Nedwin G.E.,et al.J. Cell. Biochem. 29:171-181(1985).
Kobayashi Y.,et al.J. Biochem. 100:727-733(1986).
Gray P.W.,et al.Nature 312:721-724(1984).
Matsuyama N.,et al.FEBS Lett. 302:141-144(1992).

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